Night by Elie Wiesel Annotated Bibliography Example | Topics and Well Written Essays - 750 words

Night by Elie Wiesel - Annotated Bibliography Example Night by Elie Weisel is a work that shows few characteristics of almost three modes of narration. On one hand it is the tale of the author’s own life so, it would not be wrong to say that is has the trait of an autobiography. On the other hand, it reflects profoundly on an immensely significant part of time and history, and its connection with the author’s life- thus it shows the characteristics of a memoir. It also has some potentials of a diary, as it provides thorough annals of daily occurrences taking place in the concentration camps, reminding us of the dairies of Anne Frank and the veteran African author N’Gugi Wa Thiongo’s Detained, which is a stark prison diary with exceptional fits of torments. It is an anecdote of an eternal hope that never lets the flame of hope to retire, even in the most perilous and bleak point of life. It is an intense tale of a father and his son and a metamorphosis in their relationship in an extremely adverse and difficul t situation.      Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   The author is a ‘Holocaust’ survivor. He witnessed the most grotesque and gory sides of war and its direct effect on human lives vividly. From his novel, the horror of the cruelest genocide became prominent. It is a journey of the protagonist to a new life where humbleness and security exist evenly. Night is the initial book in the trilogy by Wiesel—Night, Dawn, and Day. The trilogy reflects Wiesels condition of psyche throughout the struggle in the concentration camps and history of the Holocaust. The titles spot his switch from obscurity to radiance, with accordance to the Jewish custom of the beginning of a fresh day at nightfall. In Night, the author assumed that he wanted to reach an end of the events of pain, which have inevitably ravaged his life. Weisel is successful in making a chain of portraits of a sheer transformation of human mind under a hostile

Glomerular basement membrane diseases Essay Example | Topics and Well Written Essays - 1250 words

Glomerular basement membrane diseases - Essay Example NORMAL GBM. LEFT - a single glomerulus. There are one million of these in each kidney. RIGHT - a close up of the GBM (G) around part of one tiny blood vessel in a glomerulus (red circle in left hand diagram) Alport syndrome is the second most common inherited cause of renal failure (Turner, 2006). The disorder involves basement membranes of the kidneys and sometimes even the cochlea and the eye (Devarajan, 2008). It occurs as a result of mutations in type IV collagen genes. There are different modes of inheritance of this disease. The commonest is X-linked which is seen in 80% of the cases. Autosomal recessive inheritance is seen in 15 % of the cases and autosomal dominant inheritance is noted in 5% of the patients with Alport syndrome. Presence of 3 of the following 4 clinical presentation is necessary to arrive at a diagnosis of Alport syndrome (Devarajan, 2008). 50-80% of patients with X-linked Alport syndrome have mutations in the COL4A5 gene. Some may even have mutations of COL4A6 along with COL4A5 gene (Devarajan, 2008). There are several hundred mutations of this gene which account for most cases of X-linked Alport syndrome. These mutations include missense mutations, splice-site mutations, and small deletions. The most common mutation is substitution for glycine in the collagenous domain of the a5 (IV) chain by a bulky amino acid. This mutation results in protein-folding abnormalities. Other mutations result in interchain association and formation of the collagen network due to premature termination of protein translation and loss of the carboxy-terminal NC1 domain. Patients with autosomal recessive and autosomal dominant Alport syndrome have mutations in COL4A3 and COL4A4 (Devarajan, 2008). Most patients of Alport syndrome present during the first 2 decades of life with persistent microscopic hematuria and episodic gross hematuria. The common X-linked form of Alport syndrome leading to ESRD predominantly affects male